Background. Serum bilirubin is a potent endogenous antioxidant with anti-inflammatory properties. Several cross-sectional studies\nhave reported that bilirubin was negatively associated with metabolic syndrome. However, in recent longitudinal studies, the\nrelations between bilirubin and metabolic syndrome are inconsistent. Moreover, previous studies mainly focused on serum total\nbilirubin which is the sum of direct bilirubin and indirect bilirubin. For these reasons, the longitudinal effect of bilirubin subtypes\non incident metabolic syndrome was evaluated in Chinese men. Methods. The study cohort involved 1339 Chinese men without\nmetabolic syndrome. Metabolic syndrome was defined by the American Heart Association/National Heart, Lung and Blood\nInstitute (AHA/NHLBI) criteria, using BMI for the replacement of waist circumference. Results.There are 117 incident metabolic\nsyndrome cases (8.7%) during 5 years of follow-up among 1339 metabolic syndrome-free participants at baseline. After adjusting\nfor age, drinking, smoking, physical activity, TG, and LDL-C, the odd ratios (ORs) and 95% confidence intervals (CIs) for MetS\nincidence in the second, third, and fourth quartiles versus the first quartile of DBil concentration were 1.00 (0.61ââ?¬â??1.63), 0.57\n(0.32ââ?¬â??1.02), and 0.51 (0.28ââ?¬â??0.92) (
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